http://jpet.aspetjournals.org/cgi/content/abstract/207/2/611According to all of the research since the late 80's and early 90's, marijuana does not alter sex hormone levels in humans.
Drug Alcohol Depend. 1991 Aug;28(2):121-8.
Effects of chronic marijuana use on testosterone, luteinizing hormone, follicle stimulating hormone, prolactin and cortisol in men and women.
Block RI, Farinpour R, Schlechte JA.
Department of Anesthesia, College of Medicine, University of Iowa, Iowa City 52242.
To investigate possible effects of chronic marijuana use on reproductive and stress hormones, we assayed testosterone, luteinizing hormone, follicle stimulating hormone, prolactin, and cortisol in 93 men and 56 women with a mean (+/- S.E.) age of 23.5 +/- 0.4 years. Hormone values were compared among groups of subjects stratified according to frequency of marijuana use (frequent, moderate and infrequent; N = 27, 18, and 30, respectively) and non-using controls (N = 74).
Chronic marijuana use showed no significant effect on hormone concentrations in either men or women.Beitr Gerichtl Med. 1990;48:57-66.
[Serum testosterone concentrations in cannabis and opiate users]
[Article in German]
Friedrich G, Nepita W, Andre T.
Institut fur Rechtsmedizin, Universitat Freiburg.
The object of this study was to establish possible influences of long-term cannabis usage on plasma testosterone levels.
The plasma testosterone levels of 66 male Pakistani who for years had smoked cannabis daily or drank cannabis regularly where measured after chronic and acute intake of the drug and compared with a material of 41 normal controls, i.e. persons who did not use cannabis. An evaluation of the results showed that there were no significant differences between the two groups. No influence of long-term cannabis usage on plasma testosterone levels was found. Furthermore we wished to find out wether long-term heroin abuse showed an effect on plasma testosterone levels. The concentrations of testosterone in the plasma of 102 heroin addicts assigned to a Methadone Program were measured and compared with the values of 29 male healthy students as controls. Plasma testosterone levels were found to be significantly decreased in heroin addicts as compared to controls.
J Steroid Biochem. 1989;34(1-6):263-70.
The effects of 9-ene-tetrahydrocannabinol on hormone release and immune function.
Dax EM, Pilotte NS, Adler WH, Nagel JE, Lange WR.
Addiction Research Center, National Institute on Drug Abuse, Baltimore, MD 21224.
We investigated effects of 9-ene-tetrahydrocannabinol (THC) on endocrine and immunological function. Seventeen male volunteers entered into a double blind, randomized study to receive oral THC (10 mg t.i.d. for 3 days and on the morning of the fourth day) or placebo, after at least 2 weeks of abstinence. Plasma prolactin, ACTH, cortisol, luteinizing hormone and testosterone were not altered during or after THC, compared with baseline concentrations. Tests of lymphocyte function showed no differences compared to baseline between THC and placebo groups. As the relatively low dosing regimen of THC (10 mg t.i.d.) resulted in no alterations, another group of 6 men were administered higher doses of THC by inhalation (18 mg/marijuana cigarette) following the same dosing regimen.
No endocrine or immunological alterations were observed. When the subjects were grouped according to their history of THC use prior to admission, heavy THC users had lower prolactin concentrations than light users. No differences were observed in concentrations of other hormones or in tests of immune function.