Author Topic: Propecia Question - I'm still confused :(  (Read 11725 times)

Offline staypuft

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Hi guys,
I'm new to posting but have been reading keenly for a couple of months now.  I have been taking propecia for my hair now for almost a year but have had gyne in the form of puffy nipples since I was around 13.  I understand that propecia can lead to breast enlargement and I've read alot of the posts on here, esp those of hyp but I'm still slightly confused having just seen the doctor.

Over the past few months my breasts feel like they may have enlarged slightly so I decided to go and see my prescribing GP.  I asked the doctor to check my hormones and suggest whether I ought to see an endocrinologist regarding the influence of my propecia.  The blood tests came back yesterday and she informed me that everything was completely fine but that propecia could potentially be causing enlargements of the glandular tissue underneath.  She also conducted one of those "pinch tests" on my fat and informed me that I had gained a litte. 

I'm thinking of having surgery to have the gland removed but my question is, if my hormones are completely fine now is this any inidication that it will be ok to continue propecia or would i still need to stop it?  The posts I've read seem to suggest that you stop it but I'm not sure if this relates to a hormone imbalance or something else.

Sorry to ask again!

Staypuft

Offline puff916

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I got my puffy nips from propecia.  I continue to take it but at half the dose...because I heard that it is still quite effective but greatly reduces your chances of gyno.  My chest hasn't changed since the intitial hit. 

Offline Hypo-is-here

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I would put money on it that you have not had anything like a correct hormonal evaluation.

Unfortunately gps rarely know what on earth they are doing when it comes to such matters.

In short I wish they stopped dabbling matters that they are NOT qualified to deal with and appropriately referred patients like yourself directly to an endocrinologist who has experience of dealing with male hormones.

The American Association of Clinical Endocrinologist have often bemoaned the incompetence/lack of understanding of gps in this arena.

In their conclusion to their 2002 guidelines on Hypogonadism (low testosterone) they stated (quote is verbatim

The recognition, evaluation, and treatment of hypogonadism in the male patient are often dismissed by the patient and overlooked by the physician.
unquote

What I am seeing with people who have taken Propecia post use is a lowered level of dihdrotestosterone (DHT) and/or an elevation of Sex Hormone Binding Globulin (SHBG).

Given that hypogonadism is defined as being a lack of testosterone and or its metabolites.  And given that DHT is a fellow androgen and metabolite of testosterone, a lack of such also constitutes hypognadism.  

I guarantee that your gp has NOT even tested your DHT level.  


Also testosterone should not be viewed in isolation, it should be assessed in the context of estradiol, SHBG and other ancillary hormones.  Given that SHBG binds to testosterone and makes it unavailable to the body, given that typically only 2% of testosterone is bioavailable or free for the body to use;

Small increases in SHBG can significantly/drastically reduce the crucial level of free testosterone.

Again has your gp calculated your CT level or tested your free testosterone level or have they only looked at a single point serum/total testosterone level which is diagnostically useless?

Even in men who are not rendered hypogonadal by Propecia, they often end up with breast enlargement either due to a slightly poor endocrine balance that is not addressed or by suffering from the temporary decrease in hormonal status caused when the drug was used.

To suggest that you have gained weight and that is simply all that has happened is a little bit convenient for my liking and I think is nothing more than speculation by your doctor.

If you get yourself an endocrine evaluation of your hormonal, status I would be willing to take a look at your results for you and pass them onto other people who have also suffered from hormone problems/ people who have a great many years experience with such matter…..with a view to trying to get you professional help if required.

It would not surprise me to see either low DHT or elevated SHBG and a lowered CT or free testosterone level and think that at the very least it is worthy of greater consideration.

If you want help obtaining contact details for endocrinologists so that you may look into this further just tell me what city and state you live in.

Offline Hypo-is-here

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I got my puffy nips from propecia.  I continue to take it but at half the dose...because I heard that it is still quite effective but greatly reduces your chances of gyno. 

Whoever told you this is talking complete rubbish.

Propecia's principle ingredient of action is Finasteride.

Finasteride is used to chemically castrate men as a treatment for prostate cancer.  Finasteride directly reduces the male hormone dihydrotestosterone.  It has feminizing effects that can include reduced libido, erectile dysfunction, gynecomastia.

Saying that a little Propecia can help prevent gynecomastia is like saying that a little alcohol prevents inebriation



Offline puff916

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I was just saying that lowering the dosage will probably still help u with hairloss and reduce the chance/size of side effects.  Is there a flaw to this...please explain.

Offline Hypo-is-here

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I was just saying that lowering the dosage will probably still help u with hairloss and reduce the chance/size of side effects.  Is there a flaw to this...please explain.

What you said implied that using half the dose prevented gynecomastia development which is totally untrue.  What you are sayig now, is that in comparison to taking a full dose of Propecia, taking half a dose is less likely to cause problems and not as bad.

Yes that is true.

But!!

It does not make good logical grounds or sense to take the half dose as that poses a greater risk than taking no dose at all.

The logic you are using is trying to make things that are bad sound good and is totally flawed.

e.g

If you get hit in the face 10 times an hour with a baseball bat that is bad.  If the person hitting you slows down and only hits you in the face 5 times an hour that is not as bad...but does that make it good  ;D

I think you see my point.


Propecia contains Finasteride, Finasteride is an anti androgen and is not conducive to what it is that makes us hormonaly male.  It often causes gynecomastia and sometimes it causes difficult to treat forms of hypogonadism and can seriously reduce the quality of a mans life.

Steer clear Propeica and products containing Finasteride and do not touch them with a barge pole!!!

Unless you want to retain your hair and potentially wave goodbye to your manhood.











« Last Edit: December 12, 2006, 09:47:33 PM by Hypo-is-here »

Offline Paa_Paw

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I would think that Hypo has covered the subject quite well. And, He is totally correct.

While it is true that many men use Propecia (Finasteride) without adverse effects; it is also true that, for a small number of us, this drug can produce dire results. If you experienced an increase in breast sensitivity etc. then you are in the latter group.

What Hypo said about the need to have your hormone test levels evaluated by a competent Endocrinologist is also something that I wholeheartedly support.

Even among Endocrinologists, there are specialists. You would want to find one who has specialized in reproductive issues.
Grandpa Dan

Offline staypuft

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Heya, the reason I had to rely on my GP's assessment was that in Australia I need her referral in order to see an Endo or so I believe but perhaps I need to look at it in greater detail and determine whether or not I can see one without referral.  I agree with you that my GP's results shouldnt be relied upon.

The fat thing doesn't justify it and I know from reading these boards that losing weight has absolutely no effect in resolving puffy nipples.  My breasts on propecia haven't been at all sensitive and I haven't experienced itchy nipples or the like.

I suppose my question is that if I see an endo, and one which does a thorough examination as described, and they find that eveything is fine for me hormonally would this mean that it's safe for me to continue propecia post op?  I appreciate all the bad things associated with propecia having read alot of your posts Hypo but I suppose subjectively I almost rationalise it as the lesser of two evils for me and I've been happy with its results.

Thanks for all the help.

Staypuft
« Last Edit: December 13, 2006, 03:18:24 AM by staypuft »

Offline Hypo-is-here

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Staypuft,

The condition is known as Male Pattern Baldness.

It occurs only when two things come together A) a recessive gene B) testosterone and its inevitable derivative androgen dihydrotestosterone.  Many men have high testosterone and high dihydrotestosterone but they do not have Male Pattern Baldness because they do not have the recessive gene that is also required.

If you have the gene then as a man you are bound to have hair loss and the only way to permanently prevent that is to adversely after your hormonal status.

You are reducing what it is that makes you a man hormonally by taking Propecia.

Noticed the way you don't see many bald women?

That is because they inherently lack the same quantities of testosterone and dihydrotestosterone.

So what you are saying is that you would rather be/become more womanly from a hormonal point of view than loose some/all of your hair.

Also you would have to take Propecia indefinitely/for life otherwise your dihydrotestosterone will act upon the hair follicles.

As you get older your testosterone and dihydrotestosterone will decrease and your SHBG will increase.  This will mean that as you get nearer to 30 and then 40 and then 50 etc, your endocrine status will become more and more fragile.  Given you have already shown a propensity to develop gynecomastia with propecia use;

You can look forward to years of progressively greater problems.

Your gynecomastia will most likely be significantly worse in years to come, you may loose the ability to achieve or maintain an erection or at least have erectile dysfunction and you might also loose your libido, partially or completely (I have known this to happen with many men).

If you were in the group of men that had no reported symptoms with Propecia, those likely to have high testosterone and high dihydrotestosterone then maybe the course of events over the years would not be as great a downward spiral, but you are not in that group and your hormonal status is already in question, hence the development of the problem so far.

In short if you are getting gynecomastia now I think by the age of 50 you could certainly expect to have a very difficult to treat form of hypogonadism that will make life miserable.   Breasts, erectile dysfunction, low libido, depression/low mood and penile atrophy are all possible.  If your free testosterone is lowered via the action of Propecia on SHBG then you have the chance of increased visceral fat, possible obesity, an increase in the risk of Diabetes, and increased risk of the development of Cardio Vascular Disease (CVD), an increased risk of developing osteoporosis, an increased risk of developing Alzheimer’s….I could go on.



Here is the story of one man
 

It all started back in October 2002 but just a brief history before that. I started losing my hair in my late teens, early twenties but it has been a slow decline rather than heavy shedding. I tried minoxidil but because my hair is long it always made it look messy. When I heard about Propecia I thought what a great idea. Take a tablet each day and that’s that. It really did look like the miracle cure us baldies had been waiting for.
I started taking Propecia in October 2002. I got it from the Internet because it wasn’t available in the UK as far as I knew. I contacted Merk in New Zealand which is were my batch came from and they confirmed it was legitimate and not a cheap counterfeit. I showed them to my doctor and although he hadn’t seen Propecia before he asked me a few questions about my general health and said I would be ok to take them if I wanted to. I read the note about the 2% of men suffering from a lowered libido but also the fact that this returned to normal on stopping Propecia and also went away in men who continued to use the drug. I wasn’t dating at the time so I really did have nothing to lose, I just figured if I met someone I would stop using the drug and hey if it meant I would masturbate less I really didn’t care. I took the tablet each day for about 5 and half months. The drug had a huge affect on my hair and it grew a lot quicker and a lot thicker. All my friends noticed including my stylist, I was very happy about the positive effects.
Then I met someone I was really excited about. I immediately stopped taking Propecia and we started dating once a week. After a couple of weeks that’s when I realized things were quite the way they should be in the trouser department. I tried to masturbate but I could not get an erection even after a long time trying. Previously I had never had a problem and had always been quite a horny guy. I put it down to finasteride and thought that maybe I needed to give my body a little longer but after more time still no change. I became concerned and started searching on the Internet with Google. My worst nightmare was staring at me in black and white on the computer screen. Not one, but many cases of finasteride induced impotence. Men who had not recovered even after 3 or 4 years of finasteride I was completely distraught. I could not sleep and I could not eat, and I could not think about anything else. I cried and cried many times and the angst was almost unbearable.
I went to see my GP and told him everything, he was very understanding and made me an appointment with a doctor who was a Psychosexual specialist. I broke down in front of my girlfriend one night and told her everything and she was incredibly understanding and said she would stick by me no matter what. This was a huge relief and I was able to sleep and get back to some sense of normality. The specialist convinced me it was all in my head and he gave me some exercises to do with my partner and also Viagra to help me get over the problem. I believed him and practiced “sensate focus” with my partner and eventually used the Viagra. I did this over a 3 month period. Still suffering from impotence I decided after more research that the answer may lie within blood tests. I believed that Propecia had upset the hormone system and something was greatly out of balance. I went to see an endocrinologist and explained my symptoms as follows:
•  No morning erections and no daytime erections.
•  Great difficulty in getting or maintaining an erection for intercourse or masturbation. Watery semen
•  I felt very passive
•  My penis felt smaller, wrinkly, less full
•  My testicles hung lower and felt less full, my testicles previously would well up if I didn’t masturbate for a day or so.
•  My penis felt “disconnected” from my brain in some way.
•  Sometimes my erections stopped short and my penis would arch to the left.
•  An increase in tummy fat.
He did some basic blood tests and told me everything was normal but my Testosterone was slightly sub normal i.e. it was below the minimum range. He said that maybe I was a low Testosterone male. He said I could go on TRT either having Testosterone injected or a rub in gel. I didn’t like the sound of this as I would have to do this for the rest of my life. I also discovered that this would shutdown my testicles and I would not be able to have children whilst in this state. We agreed to leave it another 6 months and then see how things went. We did some more tests and this time my Testosterone was slightly above the minimum range. The endocrinologist was only open to basic TRT and was unwilling to try and restart my system or do any further tests to find out what was causing my the problems. As I didn’t agree he referred me to a Professor of endocrinology . I went to the appointment with great hope, after all the person I was seeing was a professor. I came out of the appointment and cried. He didn’t believe me and said it was all in my head and that I should stop doing research on the Internet. He wouldn’t treat me as everything was between the “normal” ranges in my last test. So this leads me to my present day. 3 doctors who don’t believe I have a problem and all unwilling to treat me, believe me or even investigate. I quit Propecia in March 2003 and I am still suffering side effects. I wrote to Merk a few times but they fobbed me off saying there was nothing they could do and they weren't allowed to help me. Although things have improved slightly I am far from normal. Not only is my quality of life suffering I am now increasingly concerned for my future health. No one knows yet what Propecia does to cause this condition and no one knows what the future ramifications are. Struggling with the symptoms is one thing, ignorant doctors just make the uphill struggle ten time harder. Still the fight goes on and I am currently in consultation with a doctor in the USA. I’ll keep you posted and if I could have my time again and I would never have taken Propecia. The truth is there are many men out there whose lives have been torn apart by a drug that was supposed to stop their hair falling out. I have heard of cases were finasteride has only been taken for as little as one month, the damage appears to be irreparable by the body alone and it is not known yet whether the damage can be repaired by treatment.
If you are considering Propecia exercise extreme caution and if you want my advice, stay well away.
The end


And here is a site with a link to men who have suffered from Propecia and Finasterid based products.

http://www.propeciasideeffects.com/


P.S

I have a feeling no warning will make a difference to those intent on taking Propecia.


Of note very few endocrinologists will understand the mechanism of action of Finasteride, very few will test dihydrotestosterone and very few will notice/understand its often significant impact on SHBG and impact on free testosterone. 

Most men who end up suffering pretty badly struggle to find an endocrinologist that understands what is going on; diagnosis and treatment being very hard to come by.  I have spent a VERY long time per case in order to get a number of men's endocrinologists to understand what is going on and properly diagnose and treat them.  On other occasions I have had to spend even greater time, somtimes months per case, in order to get men into the offices of endocrinologists who understand, diagnose and treat such problems.



























« Last Edit: December 13, 2006, 09:12:36 AM by Hypo-is-here »

Offline elderkid

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Hi  - Hypo-is here,

You speak as quite an authority on Propecia.  However, having researched the links on this thread it seems to be by no means certain that there is a direct link.  Having said that, seems like a good case for  - since propecia messes with the testostrone etc.  But there are some people making links to all kinds of ailments - in those forums - from depression to losing their car keys (memory loss!)

Anyway - bit of a ramble there - if Propecia can be responsible for gynecomastia, as you believe so certainly, would gyno subside after stopping Propecia?

Offline elderkid

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Is it standard proceedure for a PS - during consultation - to ask if a patient is taking Propecia.  if so what would they advise?  Do they ask?  Is it an issue for them?

Offline Hypo-is-here

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Hi  - Hypo-is here,

You speak as quite an authority on Propecia.  However, having researched the links on this thread it seems to be by no means certain that there is a direct link.  Having said that, seems like a good case for  - since propecia messes with the testostrone etc.  But there are some people making links to all kinds of ailments - in those forums - from depression to losing their car keys (memory loss!)

Anyway - bit of a ramble there - if Propecia can be responsible for gynecomastia, as you believe so certainly, would gyno subside after stopping Propecia?

Gynecomastia is listed as a possible side effect by the maker of Propecia so I am not making any exaggerated claim.

What the makers do say is that it is limited to a small number of men.  Given they have no study information to back up this claim and given I have seen dozens and dozens of men on this site alone I would strongly dispute their claim.

Listen to what I am saying, Propecia's ingredient of action is Finasteride.

Finasteride is an anti androgen, it lowers dihydrotestosterone.

Lowering androgen status is strongly associated with the development of gynecomastia.

Furthermore a licensed treatment for gynecomastia in Europe is Andractim which is dihydrotestosterone treatment.  This treatment does exactly the opposite of Finasteride and Propeica in increasing rather than decreasing dihydrotestosterone.

Finasteride is used to chemically castrate men who have prostate cancer, it is without question a drug that cause adverse alterations in the endocrine balance of men.

Men who are unfortunate enough to develop hypogonadism as a result of the use of Propecia or other Finasteride based products naturally suffer from the symptoms of that condition.

Symptoms for hypogonadism often include depression/low mood and memory loss/concentration difficulties- so that explains that link.

if Propecia can be responsible for gynecomastia, as you believe so certainly

Given the number of men that have come through this site and many others detailing the development of gynecomastia after using Propecia, given the admission by Merk that Propecia can cause gynecomastia and adverse endocrine effects, given the fact that a number of men have developed a difficult to treat form of hypognadism post Propecia use, given that Dr Eugene Shippen one of the world leading authorities in andrology has detailed such problems with Propecia use and Finasteride, given that Finasteride is a known anti androgen and is used in the treatment of prostate cancer to chemically castrate;

The case link is about as direct as one could possibly find!!!

would gyno subside after stopping Propecia?

The problems of Propecia often remain after its use.including gynecomastia.

Is it standard proceedure for a PS - during consultation - to ask if a patient is taking Propecia.  if so what would they advise?  Do they ask?  Is it an issue for them?

A PS is an expert in gynecomastia removal.  They are NOT experts or even qualified in ascertaining the causes of gynecomastia or evaluating hormones.  That is the job of an endocrinologist.  More specifically only certain endocrinologist who deal with reproductive endocrinology, and have patients and experience in dealing with hypogonadism, the sex hormones etc.

Not only will a PS rarely if ever be able to find the endocrine cause of the problem, many endocrinologists will misdiagnose this problem as well.

Because Propecia and Finasteride mainly affect dihydrotestosterone to a greater degree than testosterone and because dihydrotestosterone is rarely tested the problem is rarely found.  Even when dihydrotestosterone is tested sometimes it returns to normal and the problems arise from an elevation in SHBG and a lowering of free testosterone, again something very often missed.

With Propecia and Finasteride you are dealing with a nightmare drug if you are predisposed towards gynecomastia and have a hormonal status that is not high testosterone/high dihydrotestosterone to begin with.  Even if you do if you have high normal SHBG you can still come unstuck and in both cases you can end up with hypogonadism if you are unlucky.

I say a nightmare drug because it is very difficult to diagnose the problems it causes and as a result if you end up with real problems most gps, PS’s and endocrinologists will miss the problem and tell you everything is fine- because few people know what they are looking at or need to look for.

Offline elderkid

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You sure know your stuff when it comes to Propecia/finesteride.  I have had mild gyno as far back as i can recall (since age of around 14).  However i have been taking propecia for about 5 years now and i am starting to think that maybe i have been experiencing some of the side affects/symptoms asscoiated with this drug. I really thought it was my age (i'm 44).  I am a lot more forgetfull and seem to have lost my competetive instinct.   I suppose a bit like a mild castration!!  I have heard/seen people say that their gymo symptoms subside after they quit Propecia??

I had lypo 4 months ago - but i didnt associate gyno with propecia, again i just thought i was going south a bit more due to age!!

Offline Hypo-is-here

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You should get an endocrine evaluation with an endocrinologist/andrologist who has experience of dealing with hypogonadal patients.  In doing so you should detail your use of Propecia and say that you agev heard it can cause problems relating to DHT and SHBG/lowered free testosterone.

If you have such an evaluation and request your actual results and reference ranges I could take a look at them for you and pass them onto more men who have experinece with hormonal problems.  That way you would have an opinion from an endocrinologist and fellow patients.

I would not be suprised if you have either low normal testosterone or lowered DHT or elevated SHBG and low to low normal free testosterone.

If you tell me what city and state you live in I might be able to help you find and endo as well.




 

Offline elderkid

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Appreciate your advice.  However i am in the UK and access to these kinds of specialist is virtually unknown.  Gp's here are only interested if the teminally ill, otherwise its antibiotics or paracetamol!  if i were to mention this to my GP i am sure he would mark me as paranoid.  Thats just the way it is for the great unwashed here in the UK.


 

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