progesterone against gyno???

[brm]

A doc I talked with recently told me that he frequently advised to try progesterone gel in the chest area if tamox or AI failed. He argued that, due to competition on estrogenic receptors, progesterone could help improve a gyno initially induced by high estradiol.
Does it make sense? Or did I not  understand what he meant? Can progesterone gel really be of any help?
Thank  you.

[Paa_Paw]

Though Progesterone is actually a female hormone, it is known to have androgenic effects and it has specific influence upon the breast tissues. So, nothing you have said shocks me.

What are the specific qualifications of that Doctor to be treating Gynecomastia?

With what little I know of the actions of various hormones, This actually seems plausible even though a bit odd.

Not only that, but Progesterone cream is available over the counter without a prescription.

If you should decide to persue this line of treatment, I hope you would keep in touch and share your results or lack thereof.

[brm]

The  qualifications of the said doctor are indeed disputable: "antiageing".
I browsed the internet yesterday and found this excerpt from a
forum. Well, not much of an evidence, but...


nandi12
 
Join Date: Nov 2001
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Panerai, I believe the definition of an aromatized steroid is one having a phenolic A ring. If an enzyme creates this ring it is by definition an aromatase. The only way to get from deca to estrogen is to have an aromatase acting at some step in the process.

MisterX, it is certainly true that estrogen upregulates the progesterone receptor. However, the role of the progesterone receptor in gynecomastia is not known. As I understand it, current thought is that progesterone may indirectly contribute to gynecomastia by stimulating prolactin release. As I pointed out earlier, RU-486 has been reported to cause gynecomastia, so progesterone blockade is no guarantee against gyno; on the contrary it may contribute to gyno. This makes sense because progesterone is thought to downregulate the estrogen receptor. Studies have shown that when the action of progesterone is blocked by RU-486, there is an upregulation of the estrogen receptor. (1), (2).

While it is clear from many studies that IGF-1 is a factor in breast cancer development, its role and the role of GH in gynecomastia are unclear. Unlike with breast cancer, tissue from gyno patients is not neoplastic. That said, gyno has been reported as a side effect from GH use. (3) This may very well result from the fact that GH binds to the prolactin receptor. (4)

I would not rely on the single published study of winstrol binding to the progesterone receptor to assume winstrol can prevent gyno. There are no studies showing that this is the case. It worries me that newbies will take this to heart and end up regretting it.

(1) : Int J Biol Markers 1995 Jan-Mar;10(1):47-54

Progesterone agonists and antagonists induce down- and up-regulation of estrogen receptors and estrogen inducible genes in human breast cancer cell lines.

[brm]

Hypo, any thought about this?

[Hypo-is-here]

It is VERY questionable as to any benefit in treating men, some anti aging doctors believe it helps balance the male endocrine system and prevent estrogen dominance while others say it is nevertheless overtly estrogenic and a DHT antagonists and likely to cause gynecomastia.  I have not had first hand experience with it but I would err on the side of caution and stay well clear of it.

If the andrologists who are dead against it are even half right then it would be very unhelpful to any man with gynecomastia.

[moobius]

excess progestin can make one MORE likely to get gyno...

progesterone, estrogen, & IGF can contribute to gyno. estrogen is the easiest to block...

IMO, having high estrogen levels and adding extra progesterone to the equation = bigger moobs