ya but do u know why >? lol I know DHT has specific properties of supressing estradiol. I'm sure test has some kind of mechanisim at supressing expression of the various ests 2. But does it in itself combat breast tissue?
people with hypogandisim even dont nec have gyno. Even low test lvls dont mean ur going to get gyno. The way i understand it .. is it's all EST.
It is is categorically NOT just to do with estrogens.
Starting with DHT
I'll explain DHT from the point of view of what happens if it increases- how it does is not so important from the point of view of the explanation.
DHT is a potent androgen in its own right.
Like all Androgens and estrogens DHT is recognized by the Hypothalamus. When DHT increases the Hypothalamus down regulates GnRH in doing so it instructs the pituitary to reduce gonadotrophins.
With reduced LH/Downregulated LH the testicles leydig cells hypertrophy.
This results in lowered testosterone production.
When you have lowered testosterone via this mechanism you reduce the fuel for estradiol the most potent estrogen.
You see estradiol and DHT are the major metabolites of testosterone (a prohormone) . It is what testosterone is most readily converted to.
Without oxygen you cannot have a fire, it is what fuels a fire, likewise testosterone is usually required to fuel estradiol.
So increasing the androgen DHT reduces testosterone, this as a result reduces (the fuel for estradiol) estradiol.
With reduced estradiol but with the increased androgen DHT (which itself cannot convert to estradiol) you have an increased androgen to estrogen balance and this can reduce gynecomastia if it is in its proliferation phase.
Which is why DHT Andractim has been shown to reduce gynecomastia in 75% of cases and resolve gynecomastia in 25% of cases in controlled studies as reported by Glen D Braunstein M.D endocrinologist in his white paper on gynecomastia.
Testosterone like DHT sits on one side of the balance with other androgens and all other estrogens the most potent of which estradiol sit on the other.
Of course it is further complicated by intracrinology, given the fact that many hormones can change from one kind to another- testosterone being on the one side of the balance being able to convert to estrogens on the other side of the balance.
As a man you need your Androgens to outbalance your estrogens by x amount, otherwise you have a good chance of developing gynecomastia.
The very reason that men who abuse steroids (such men account for 25% of all gynecomastia sufferers) don't tend to develop gynecomastia on steroids is because despite having significantly elevated estrogens their Androgens out balance them in the androgen to estrogen balance/ratio.
When they stop abusing the steroids those who don't take PCT as these guys term it are left with the same high levels of estrogens, but now they are unopposed as they no longer have high androgen levels.
High estrogen that previously didn't cause gynecomastia now does.
It is all to do with the ratios/balance of androgens to estrogens and ancillary hormones.
The reason some men with hypogonadism do not have gynecomastia is because having low testosterone means that quite a few of them have little testosterone to convert into estrogen in the first place. So these men have low testosterone and low estrogen.
For some unfortunate reason some men with low testosterone have additional complicating factors that result in low testosterone and high estrogen such as;
Chromosomal abnormalities that mean an altered expression of androgen and estrogen receptors and related effects, as in Klinefelter and Kallman syndromes.
Metabolic syndromes/problems also cause this situation such as hemochromatosis.
Poor liver function
Poor kidney function
As the above two can result in high levels of SHBG or in poor metabloization of estrogens.
Just to further illustrate the importance of the balance/ratios of androgens to estrogens;
You can develop gynecomastia with normal levels of estrogens if you testosterone is low, because in such a situation you can have a poor androgen to estrogen balance/ratio.
Lets say you had 10,000 dollars in the bank (think of that as androgens) and you have 3,000 dollars worth of bills (think of them as estrogens).
That might be thought to be ok.
Now lets say your bills (estrogen) are only 2,000 dollars, you might think no problem, but what if you only have 1,000 dollars (androgens).
As you can see, how much a pain in the ass your bills (estrogens) are is dependent upon your how much money (androgens) you have.
You can never really look at estrogens independently of androgens as the balance/ratio between the two is crucial.
Which is why testing and considering hormones in isolation is absurd and something that a good reproductive endocrinologist would not do.
I have waffled and the analogies were made up on the spot so are a bit daft, but hopefully you get the picture.
I could have explained all of this in exacting medical detail, but I thought that it was better in this form.
Topic: Which med do you guys suggest for self-treating? (Read 5150 times)
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