Author Topic: Can Depression due to gynecomstia lead to suicide?  (Read 22822 times)

Offline Worrier

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Hypo, I know you do indeed know a lot about testosterone deficiency and that at the end of the day an informed paitient is better than an uninformed one, but are you suggesting that I don't take my GP's advice on serious problems like testosterone deficiency?

The fact is testosterone deficiency can be caused by many serious problems (some life threatening) and if a GP mistakenly diagnosed someone as having a chemical imbalance of the brain instead of this he/she would be in serious trouble. If a GP feels there is cause for concern he/she will refer you to an endo. I would put faith in my GP rather than an anonymous source on the internet or Dr eugene Shippen or whatever his name is.

If phantoms has quoted correctly what a Gp follows when looking at this issue than that is fine by me. They have medical degrees and many years of experience. I really don't think they would like the fact that you are suggesting that their guidence is wrong.....


Offline Hypo-is-here

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Quote
Arrogant hey?  I counted no less than 15 gross assumptions you have made about me.  Thing is, I don't tend to plaster my whole life onto the net to convice people of who I am or what I know.

So maybe I copied a thing or two from the net for my posts. Maybe I didn't.  Maybe I should give up my day job cuz selling in hormones in gynaecology and andrology to GPs and consultants on a daily basis according to you it just ain't my thing.  Once my sales for Nebido and Testogel slump and my bonuses stop rolling in I'll know I am not good at what I do, I'll quit.  Until then I will tolerate your attitude problem.

To assume is to make an ASS of U and ME.


The problem is that you do copy some things from the net and you get it wrong sometimes.

That is the point!

I made no assumptions about you whatsoever.

In fact given some of the things you have been saying I made it my business to find out about you.  Interestingly there is as much about your life history in the 140+ posts that you have made than there is in all of mine.  Not that there is anything wrong with that.

I found out that you have said things that imply that you something you are not;

Quote
Thanks for that Hypo-is-here
As it happens, I do understand.  I work in andrology and more specifically male HRT.
.


I looked into your background and found this;

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Hello ChristianTroy

I had surgery nine days ago.

1) I went back to work four days after surgery ( I am a sales rep, so lots of driving and I was ok).


Now there is a big difference from being involved in Andrology and understanding hormones and selling some products.  

The fact is I knew exactly what you were before making my comments so I wasn't assuming anything.

You are a sales rep.

Does this mean that a realtor/estate agent is an expert in the design and building of houses?

NO

I am sorry if you find this offensive but I am just speaking my mind.

The fact is you are not a doctor; you are not involved in Andrology apart from as a sales rep.

A) You should admit you do not speak with the eminent experts in this field about the in depth details of testosterone deficiency and its diagnosis- I DO!

B)  You do not speak with the actual numbers of patients that I do.  This means you do not have an in-depth understanding of the realities of the diagnostic procedures and symptoms etc that such men go through- I DO!

C)  You have no first hand knowledge of the symptoms or diagnosis of hypogonadism- I DO!

D) Your knowledge of Andrology is crude and this is because you have never studied Andrology and in fact have no medical qualifications in Andrology and neither are you a patient who sees it matters from the other side of the fence- I have studied the condition and understand it as patient and someone who speaks daily to fellow patients and endocrinologists!

E) You have very little if any interaction with actual endocrinologists when it comes to discussing the actual details of these conditions- I DO!

So in short you are not a doctor of any type having no qualification in Andrology and you are not a patient who meets with the above all the time and studies the condition from the patients position.

But lets do something radical and dispense with the “you and me” of the argument (you can respond of course to what I have said above but once you have lets concentrate on the facts below).

I didn’t want to argue with you in the first place I only wanted to ensure that people were not be misled by some of the things you have got wrong.  My reason for this is that I have been putting in hundreds and hundreds of hours on this site and hypogonadism support groups for years to ensure that people get the correct information.

I do this so that people do not go undiagnosed for years as I did and many of my fellow sufferers.

If your information means that one man is mistaken about his situation then that is one man that could end up in 13 years time with osteoporosis as happened to me.

One man is one man too many for me, which is why I am here.

Let’s see what are we actually disagreeing about here and resolve the issues sensibly and then move one.

I said that a comment of yours was totally wrong.

It was this one;

Quote


But that only applies to men defined as having low testosterone (below 12nmol/L but this figure varies from country to country)
.


I am stating this is factually wrong.

It is explained at great length that this is utterly wrong and outdated thinking by Dr Eugene Shippen in his book The Testosterone Syndrome.  It is also explained by Dr Malcolm Carruthers in his books The Testosterone Revolution and Androgen Deficiency in the Adult Male.  I can tell you this having read all of them and having spoken at length with these eminent professionals.

Without copying their comments verbatim I will give you the idea of what he has said (of course you are welcome to go and buy the books and put in hour after hour getting to try and understand a little more).

Symptoms are more important that blood tests alone.  Testosterone deficiency should be diagnosed on the basis of symptoms in conjunction with blood tests or additional testing of the HPTA, genetics and scans etc. Blood tests should only be used as a guide, not a rule when considering testosterone deficiency.

The reasons that bloods alone are flawed and in themselves cannot offer conclusive answers are many but I will detail the main issues;

1
The testosterone reference range for adults does not take age into account; this means that a 90 years old man and a 18 years old man will be deemed to both be normal if they are right at the bottom of the testosterone reference range.  This is a flaw inherent in the reference ranges.

2
Gps tend to only test testosterone and have a very limited knowledge of hormones.  When testosterone is tested what does it show us?

It shows us whether we are within the range or not.

However the fact is it doesn’t tell us whether or not we are at the point in the range that our bodies require.

Obviously if you test X number of healthy men you will find a range of testosterone values, some men will naturally be fairly healthy with quite low serum/total testosterone levels and other men quite healthy with more middling levels whilst others quite healthy with fairly high levels (for a very good reason).

It is not a coincidence that there are men with high and middling levels of testosterone, the body has not got it wrong.  If these men with high or middling testosterone see a substantial drop in their testosterone level whatever the cause then they can still be within the so called normal range.  In fact their testosterone level can be much less than their body requires and they can have all the symptoms of testosterone deficiency.  This fact is detailed at length by Dr Eugene Shippen.  So all the normal range means is that 95 percent of people will fall with these parameters as seen in gaussian graphs.  It does not mean that any individual in the range is necessarily at the point in the range that is correct for them.

3
It is a long known fact that serum/total testosterone offers very limited diagnostic value.

If SHBG is high then a man can be testosterone deficient, irrespective of what level of total testosterone they have.  This is because SHBG is the transporter protein that binds to testosterone.  98% of serum/total testosterone in the body is typically bound to SHBG making it unusable by the body.  SHBG binds to androgens and estrogens, but it binds to androgens with greater affinity.  This means that even subtle increases in SHBG can lower free testosterone levels and relatively lead to an increase in free estradiol.

The result of all this is that a man with high SHBG can have a normal or even high testosterone level and still be testosterone deficient.

Which is why a serum testostrerone value of 12nmol/l does not prove what you were saying and why I have told you it was wrong (I wasn’t just being awkward).

4
Elevations in Prolactin and Estradiol have the same effect in lowering free testosterone as the above.

For these reasons a single serum/total testopsterone assay is NOT diagnostically usefull in proving that an individual has or in fact doe not have testosterone deficiency- one way or the other.

5
The single point measurement also misses out the need to test Luteinising Hormone.  LH is a messenger hormone that can often reveal that the body is crying out for more testosterone despite a seemingly normal testosterone level.

This again is not taken into account by the single point testosterone assay.  Also this is something rarely tested at gp level.


6
There are many men with abnormalities that relate to the androgen receptor.  Everything from CAG repeat defects, PAIS (Partial Androgen Insensitivity syndrome) to Klinefelter Syndrome.


I can go and get evidence right now that shows men with Klinefelter Syndrome who have testosterone levels above 12nmol/l.


7
Having detailed all the above I will detail the fact that you yourself have even disagreed with your own comments on the matter (you are inconsistent because this is not an area where you are sufficiently knowledgeable).

In you do a search and the search engine works you and other people will see that you sated that the bloods had their limitations and that they were not the be all and end all in one of your posts.

Number 138- your 138th post on this site to be precise.

Now how can you blame me for stating the truth and disagreeing with you when you can’t even manage to agree with yourself?


What else do you disagree with in terms of what I had to say?

I stated that I known men to try to commit suicide because they were testosterone deficient and that I have known many men that were on anti depressants for years- both never knew they were testosterone deficient.  Many of them had very limited symptoms with depression being one of them.

This is a FACT!!

Are you disagreeing with me?  

Because if you are I will show you their testimonies!

In fact here is one- I can present hundreds of them.

http://www.androids.org.uk/stories.html


P.S

If I have told you that you were wrong at any point and disagreed with you it is because you have been wrong.  If I have worded things in a way you find disconcerting or that have been unfair in any way then I apologise.  

You have contributed some very good posts on the site like I have said and I know you are trying to help- and I am not saying that to patronize you and in fact if I have at any point again I apologise.

I would be quite willing to give my phone number privately so that we could talk about this subject.  You are clearly an intelligent articulate guy and someone I would have thought could help me in trying to put a message across about the need for pathology testing for men that have gynecomastia.

I would like to show and detail for you many things which I am sure would change your outlook.

Again I am being brutally honest not patronizing.

I hope you do not feel upset about what has gone on and you can see why I have said the things I have.

I would hope to not argue in future, particulary as you have been doing a good job of helping people out in so many other posts.

Quote
And now... to an actual question.

My Endocronologist got approval for me to receive Testoterone gel.  Which I daresay is much easier than the injections I used to have to shot into my thighs.

I have stayed off it since surgery for fear that it might bring back the onset of Gyno all over again.  I am being paranoid?  Do I have cause to be concerned?  Should I go back to my gel?

Any and ALL feedback is appreciated.

Fajha.



Most endocrinologist and surgeons like to consider gynecomastia surgeries when the gynecomastia is in a stable/settled state.

For this reason quite often endocrinologists will tell men on testosterone replacement therapy to not have a surgical procedure for 6 months to a year on treatment, so your concern is legitimate.

Certainly being on the treatment and waiting for surgery whilst letting your hormones settle is the preferable way to go about things.

The form of treatment is for you and your endocrinologist to decide.

The fact is there is no one perfect treatment and it is very much a cases of horses for courses with what works for some men not working for others.

With regard to gynecomastia, some treatments elevate estradiol much more than others.

For this reason many men that suffer with gynecomastia and low testosterone tend to take TRT that has a low conversion to estradiol.

Testosterone ethanate or proprionate injections
The best treatment for low conversion of testosterone to estradiol (it differs between patients) but
tends to be Testosterone ethanate or proprionate injections using the new weekly protocol.

Testim, Androgel or Tetsogel as it is called in the UK  (Many men do quite well on these products)
Increases estradiol via its delivery mechanism of going through the skin and the effects of aromatase.   But it tends to be far better than;

Old traditional testosterone ethanate injections
250mgs given once every two to three weeks.  Many men do poorly on this TRT.

Nebido
Is a relatively new long acting testosterone ester/product that uses testosterone undecanoate.

Although testosterone undecanoate has a low conversion rate to estradiol.  So far many men have been quite poor on it.  This is because although testosterone undecanoate converts less testosterone to estradiol per mg it is injected in large quantities.

It is usually given as a 1000mg injection.  Many gps and endocrinologists like it because with one injection a patient can go away and there is little maintenance.  But ALL the patients I have spoken to so far are unhappy woth it and their estradiol levels have increased quite high as a result of the quantities injected.

Testosterone patches scrotal and non scrotal
The patches converted very little testosterone to estradiol but Both are rarely used today due to their inconvenience.  


Testosterone implants
These can be expensive and are difficult to dose correctly.  If dosed correctly they are very effective and many men who try them never change to another form of therapy.  If dosed correctly estradiol levels do not typically increase to the levels seen in gels, however many endocrinologists have failed to dose correctly over the years and large dosing can and often does lead to serious elevations in estradiol.

Testosterone undecanoate tablets or Testocaps
From my personal experience and from the experience of many other men these are only helpful for elderly men with mild deficiency and are just not an effective form of TRT.


As I said it is for you and your doctor to decide what is best for you.  I have only detailed the issues with estradiol.  There are many otyher factors in choosing an appropriate testosterone replacement therapy regime.


Many men try the gels first as these are easy to dose and go from there.  You might be someone who would do well on the gels.

You can only tell by trying them and subjectively seeing how you are and having a close eye kept on your pathology results.

If your estradiol level does become a problem you have the option of switching treatment or having some form of anti estrogen or aromatase inhibitor prescribed (at least you do if your endocrinologist is forward thinking).


Quickly jumping to the main point of your question.

Will going on the gel increase your gynecomastia.

The answer is it might.

With a lot of men it doesn’t- but with a significant minority it does

It did with me.

It all depends on your body chemistry, why you are deficient in the first place, the dosage of gel etc.

I would say that if you are deficient in testosterone you should be on treatment as it is unhealthy not to be and this should come before your issues with gynecomastia.  


You would be better placed having the testosterone deficiency treated while your doctors adopt a watch and wait approach regarding the gynecomastia.

Some men see gynecomastia increase and then settle, some see no change, a few men see an improvement and some like me see it get worse.

But what you can do is get on the correct form of treatment that works for you, get your hormones balanced and then go for the operation knowing that it has less chance of returing in the long term.

You can get the opinion sof many other patients regarding what i have said at the support groups below.

http://health.groups.yahoo.com/group/hypogonadism2/

A US group for which you need to register.

And a UK group for which again you would need to register.

http://www.andropause.org.uk/newforum/forum_frameset.htm

Additional helpful information can be found here

http://www.androids.org.uk/

In total you will be able to ask your question of the very people who have experienced the effects of al the said medication.  People are there to help you- a culmination of hundreds of years of experience when you add up all the people and experiences.

Some of the guys have been dealing with hypogonadism and said medications for over 25years.

I hope that helps.



Quote


Hypo, I know you do indeed know a lot about testosterone deficiency and that at the end of the day an informed paitient is better than an uninformed one, but are you suggesting that I don't take my GP's advice on serious problems like testosterone deficiency?

The fact is testosterone deficiency can be caused by many serious problems (some life threatening) and if a GP mistakenly diagnosed someone as having a chemical imbalance of the brain instead of this he/she would be in serious trouble. If a GP feels there is cause for concern he/she will refer you to an endo. I would put faith in my GP rather than an anonymous source on the internet or Dr eugene Shippen or whatever his name is.

If phantoms has quoted correctly what a Gp follows when looking at this issue than that is fine by me. They have medical degrees and many years of experience. I really don't think they would like the fact that you are suggesting that their guidence is wrong.....



I am telling you that your gp is NOT an expert when it comes to hormones and testing for them.

I am telling you that the only person that should be consulted is someone who is an expert and that is an encocrinologist who has an interest in reproductive endocrinology.


I understand this is hard to accept but it is the truth.

OInce again I will quote The AACE verbatim (American Association of Clinical Endocrinologists) in their conclusion to their national guidelines on hypogonadism.

The recognition, evaluation and treatment of hypogonadism in the male patient are often dismissed by the patient and overlooked by the physician.
Unquote


The top authority in the USA is basically bemoaning the inability of gps when it comes to this subject matter.

Also Dr Eugene Shippen is one of the worlds foremost authorities on testosterone deficiency (although I can understand why you would not trust in something you are told on the internet and a doctor who you do not know, even if he is one of the best in the world).

Hopefully you believe what I am saying regarding the AACE.

If not I guess I will have to go and get the guidelines so you can read them for yourself.
« Last Edit: February 01, 2006, 09:32:48 AM by Hypo-is-here »

Offline Hypo-is-here

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One last thing that I just want people to bare in mind.

I have been working my butt off to try and raise awarness of testosterone deficinecy and its connection and relevence to gynecomastia (which is an associated condition) for years now, both on this website and others.

I have over 1000 posts on the board and that is before considering the fact that I have dealt with 1000s of pms and spent hundreds of hours helping people obtain information and help people gain consultations with endocrinologists across the world.

I have literally put dozens and dozens of people in touch with endocrinologists and had hundreds of people thanking me for working my butt off on their behalf.

It can be very hard, boring, repetative and sometimes incredibly frustrating trying to help to deliver this.

And there is always one person or another who will insult me or try and shoot me down or put out information that is factually incorrect or misleading whether they mean it or not.  

This is something else that can be very frustating when putting this much time and effort in.

I have high standards but sometimes I can't live up to them in every instance no mater how hard I try.

It is sometimes even like trying to walk a high wire.  Trying to do my best to put the truth out there whilst not conflicting with other people out there.  But sometimes I just cannot achieve that balance.

Where this has happened like in this thread I want you to know that I am trying my utmost to not just argue for the sake of it, but because I value the need to get the truth out there.

Retaining the poxy analogy for a moment.  

Sometimes I lose my balance and fall off that high wire.

I don't communicate maybe as well as I would have wished with a given person or in a given instance.

But trust me when I say this;

The information I am bringing to the site is of the highest quality and I am trying my damdest as I always have on behalf of all men here to rasie awarness and help people.

If you are someone who is reading who has felt somehow slighted then please understand this is not something I wish even if it is something I may have done.

I want to work with anyone and everyone when it comes to putting the best information out there in the hands of gynecomastia sufferers.

P.S

I didn't have to write this I am trying to detail where I am coming from and am even saying that I mess up just like any human does.   It is not some Politically correct mush.  I am absolutley genuine and certainly I am prepared to apologise hold out a hand or in fact do whatever it takes so that the people who I am trying to help benefit.




« Last Edit: February 01, 2006, 08:32:39 AM by Hypo-is-here »

Offline phantom

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Quote
And now... to an actual question.

My Endocrinologist got approval for me to receive Testosterone gel.  Which I daresay is much easier than the injections I used to have to shot into my thighs.

I have stayed off it since surgery for fear that it might bring back the onset of Gyno all over again.  I am being paranoid?  Do I have cause to be concerned?  Should I go back to my gel?

Any and ALL feedback is appreciated.

Fajha.


Hello Fajha

Only your endocrinologist can answer that question for you.  I am governed by the ABPI (Association of the British Pharmaceutical Industry).   Their code of conduct forbids me talking about my products other than to health care professionals.  This is to prevent medical sales persons promoting prescriptions only medicine (POMs) to the general public.  In the UK  POMs are not allowed to be advertised to the general public, which is not the case in many other countries.

All I can say is that it is your Endocrinologist that has a duty of care for you.  I wish I could help further, I am sure you understand.

Offline Fajha

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Thank you Gentlemen.  I appreciate all the feedback.

I will be seeing my Endo here in the States next week, and I will ask about this then.

Again - I hope you both can settle any differences you might have.  Medicine is not a perfect science and the sharing of thoughts, findings and ideas has always led to progress for humanity.

Fajha.

Offline bignipCT

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Quote
Where low testosterone is a cause of gynaecomastia, it can affect men in different ways depending on their age.  In young men and boys it can cause late onset of puberty or not occurring at all.  In adult men it can have a negative effect on libido, reproduction capability and general well being.  Common symptoms include:

Muscle weakness
Tiredness
Lethargy
Increased body fat
Lipid disorders
Anaemia
Insulin resistance
Erectile dysfunction (impotence)
Loss of libido (sex drive)
Decreased shaving frequency
Hot/cold flushes
Sweating
Loss of body and facial and pubic hair
Smooth, fine, wrinkly skin
Shrinking testicles
Osteoporosis


i dont have any of these symptoms, is this all just gonna hit me when im older ???

Offline Hypo-is-here

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BignipCT,

What makes you think you have low testosterone (hypogonadism)?


Offline GynoVict1m

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You know this is very weird, this whole day went horrible, like every other day in my life. I took up smoking about a year ago to try and relieve my depression and other things, nothing has worked. Its not only the gyne that depresses me its just everything. Tonight for some reason I was just searching through written suicide letters and I cannot tell you if i was considering it or not because I dont know myself. Depression apparently runs in my family I believe. I am only 16 and plan on getting help when I am old enough to drive because I guess I am kind of embarrassed to admit to my family that I am psychologically F'ED UP. I at a normal weight, so obesity was never one of my problems or anything. I just get depressed very easily and am very insecure.
As for now I dont know what to do. But its nice coming to this board and seeing others who I can relate my problems too, you are the only real ones I can talk to about this.
« Last Edit: February 02, 2006, 04:11:00 PM by GynoVict1m »

Offline silly_guy

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Hey GynoVict1m,

Just sit tight and keep hope up.  One thing I've learned in life, is there's always a solution to everything.  Might involve some amount of compromise (and ingenuity), but stay focused on finding the solution and you'll get there.  

Try not to let the bad stuff break your focus.

Later,
Silly_Guy

Offline phantom

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Quote
You know this is very weird, this whole day went horrible, like every other day in my life. I took up smoking about a year ago to try and relieve my depression and other things, nothing has worked. Its not only the gyne that depresses me its just everything. Tonight for some reason I was just searching through written suicide letters and I cannot tell you if i was considering it or not because I dont know myself. Depression apparently runs in my family I believe. I am only 16 and plan on getting help when I am old enough to drive because I guess I am kind of embarrassed to admit to my family that I am psychologically F'ED UP. I at a normal weight, so obesity was never one of my problems or anything. I just get depressed very easily and am very insecure.
As for now I dont know what to do. But its nice coming to this board and seeing others who I can relate my problems too, you are the only real ones I can talk to about this.


Hello gynovict1m

You don't sound at all happy.  One of the classic symptoms of depression is suicidal thoughts.  This does not mean you are full-steam on a track to ending your life.  But suicidal thoughts is something your doctor would like to know about.

Unfortunately, many people living with depression don't want to admit they are depressed for fear of rejection - which can make the situation worse.  It's a horrible cycle to get into.  One small comfort for you is that it is estimated that around 5% of the general population could be clinically defined as depressed at any given time (so one in twenty) and around 30% of people will suffer with some form of depression in their lives.  So you are most certainly not alone.

Is their anyone in your family you can confide in?  I don't know your personal circumstances, but I am sure once you are able to share your feelings with someone you are close with, it will take the edge off what you are feeling.

If not, I cannot urge you enough to see your doctor.  He or she will take you very seriously.  No matter how small, frightened or alone you feel you doctor is very experienced at dealing with all manor of psychological issues.  This is a place where you have nothing to loose but so much to gain.

I don't know where you are from, but here is a link that might be of help to you (UK).

http://www.samaritans.org.uk/

If you are outside the UK click on this website:

http://www.samaritans.org/talk/questions.shtm#

and click on Frequently Asked Question number 6 where other international organisations are listed.

Best wishes.
« Last Edit: February 03, 2006, 03:59:17 AM by phantom »

Offline bignipCT

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BignipCT,

What makes you think you have low testosterone (hypogonadism)?




i thought this was the reason all of us have gyno, besides the ones who got it from medication or steroids.

Offline Hypo-is-here

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No not at all.

10% of all gynecomastia sufferers have low testosterone (hypogonadism).

8% suffer from hepatic problems.

2% suffer from hyperthyroidism.

2% testicular malignancies

3% of other underlying conditions of less that account for less than 1% each.

In total 25% of all sufferers have underlying conditions, which is why I always bang on about the need for pathology investigations with endocrinologists.

But most men here do not have low testosterone and certainly you shouldn't presume you do.

Odds are you are healthy, investiagtions are about  ensuring this is the case.

At its very core gynecomastia ia due to a hormonal imbalance whether that is of a temporary nature as in puberty or more permanent as those situations listed above.













Offline phantom

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Hello BigNipCT

There are a wide range of reasons why men get or have gynaecomastia.  In the first weeks of foetal development we are all arguably all female, until chromosomes and hormones get to work on us to change us into males.

But, in effect we all have the plumbing to be female, even after we are born (why else do we need nipples?)

Many men have glandular or breast tissue (figures vary, I tend to peg it at around 60%).  The amount we have varies.

My surgeon described my gynaecomastia as moderate to severe, but still within the normal range for a normal male.  In fact  my testosterone levels are higher than the normal range according to one of my Endocrinologist customers.

So some of us are just a little unlucky where mother nature is concerned in the amount of breast tissue she gave us!  So there is one explanation, I'm sure there are others that other members of the forum could contribute.

Hope that helps.

Offline bignipCT

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ive always been a healthy guy, no medical probs what so ever.....I guess my mom was right when she said "oops i musta gave you my big nipples."

Offline 6655321

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Yes it can lead to suicide.  I'm considering it at the moment myself.


 

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