Right now I'm debating about whether or not to try Andractim. I'm seeing a lot of mixed reviews about this gel, but I do believe it is worth a try for the price. If that works, great...but realistically it seems like surgery is the only surefire method.
Andractim is essentially topical DHT cream, right?
This will *probably* work better than that all herbal bull$hit remedy. Andractim is highly androgenic so it will combat estrogen to some degree. Transdermal DHT is not approved by the FDA so you will need to order it from Canada, Europe, or maybe Mexico. It will not remove glandular tissue that has already been formed it will temporarily shrink the masses.
Andractim is essentially transdermal DHT which may make your hair fall out (depending on how prone you are to male pattern baldness) or wreck havoc on your prostate (depending on how old you are). Using a highly androgenic substance like DHT is generally a poor choice for combating estrogen. Something like Arimidex or Femara would be a much better choice in my opinion.
The premise behind Andractim is that DHT temporarily binds to the aromatase enzymes around the breast glanular tissue so that other substrates such as testosterone will not be able to bind to it, and an anti-aromatase effect is achieved similar to a SERM (Selective Estrogen Receptor Modulators).
However, the down side to Andractim is that it is only effective for a brief period of time. Two hours after application the majority of the DHT has left the chest area and has travelled to other parts of the body in the bloodstream. Thus the Andractim is no longer effective and the DHT is free to travel around the body potentially causing other side effects. However, some people seem to have seen decent results from Andractim, but more have complained about it being in effective.
Arimidex or Femara will be far more effective than Andractim in reducing the total amount of estrogen in your body so that there is no estrogen to bind to these enzymes to begin with. The half-life of Arimidex or Femara is longer than andractim (3 days) so it will be much more effective in doing this.
I would say that Arimidex or Letro could take up to 10 weeks to be effective in reducing the size of any glanular tissue. It might take 2 rounds of 10 week Arimidex or Letro doses for the tissue to shrink completely.
However all this being said, there will always be some cases with densely packed glanular tissue that cannot be resolved with anything but surgery.
Look at the size of the glanular tissue removed below. This is densely packed tissue. I would imagine that not even Arimidex or Letro would completely disolve that large mass of glanuar tissue. However it is definitely worth giving letro a try before considering surgery.